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- ArticleLittle P, Curtis P, Coutelle C, Van den Berg J, Dalgleish R, Malcolm S, Courtney M, Westaway D, Williamson R.Nature. 1978 Jun 22;273(5664):640-3.Human globin cDNA-derived recombinants with plasmid pCR1 have been prepared for use as specific hybridisation probes and for the partial sequencing of alpha-, beta- and gamma-globin genes.